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Literature summary extracted from

  • Steckelbroeck, S.; Nassen, A.; Ugele, B.; Ludwig, M.; Watzka, M.; Reissinger, A.; Clusmann, H.; Lütjohann, D.; Siekmann, L.; Klingmüller, D.; Hans, V.H.
    Steroid sulfatase (STS) expression in the human temporal lobe: enzyme activity, mRNA expression and immunohistochemistry study (2004), J. Neurochem., 89, 403-417.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.6.2 0.0043
-
 dehydroepiandrosterone sulfate pH 7.5, 37°C, subcortical white matter, female Homo sapiens
3.1.6.2 0.0044
-
 dehydroepiandrosterone sulfate pH 7.5, 37°C, cerebral neocortex, male Homo sapiens
3.1.6.2 0.0059
-
 dehydroepiandrosterone sulfate pH 7.5, 37°C, cerebral neocortex, female Homo sapiens
3.1.6.2 0.0074
-
 dehydroepiandrosterone sulfate pH 7.5, 37°C, subcortical white matter, male Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.6.2 membrane STS activity is enriched in the membrane fraction of the temporal lobe Homo sapiens 16020
-
3.1.6.2 additional information subcellular distribution of STS in the temporal lobe Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.2 additional information Homo sapiens STS may play an important role within the CNS ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.2 brain fetal and adult, age- and sex-dependent STS expression pattern, mature temporal lobe: about 10times lower expression than in the placenta, STS activity and expression is twice as high in cerebral neocortex than in subcortical white matter, STS is detectable in adult neurons as well as in fetal and adult Cajal-Retzius cells Homo sapiens
-
3.1.6.2 additional information STS expression pattern Homo sapiens
-
3.1.6.2 neuron adult Homo sapiens
-
3.1.6.2 placenta about 10times higher expression than in the temporal lobe Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.6.2 additional information
-
 no sex- or age-specific differences in cerebral STS activity Homo sapiens
3.1.6.2 0.0000128
-
 pH 7.5, 37°C, subcortical white matter Homo sapiens
3.1.6.2 0.0000265
-
 pH 7.5, 37°C, cerebral neocortex Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.2 dehydroepiandrosterone sulfate + H2O
-
 Homo sapiens dehydroepiandrosterone + sulfate
-
 ?
3.1.6.2 additional information STS may play an important role within the CNS Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.6.2 STS
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.6.2 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.6.2 7 7.5 STS from temporal lobe Homo sapiens